The optical rotatory properties of the beta-configuration in polypeptides and proteins.

Partial molar rotatory powers and optical activity in proteins and polypeptides. I. The fully extended chain and the antiparallel beta-pleated sheet.

Partial Rotatory Powers.-Recent experimental data on the circular dichroism spectra of a planar, cyclic, model compound, L-5-methyl pyrrolid-2-one," 2 and on the vacuum ultraviolet-absorption spectra of poly-L-alanine,3 as well as recent theoretical work on the spectra of simple amides4 and polypeptides,5 indicate that there is much to be clarified before a truly satisfactory theory of optical ...

Circular dichroism and optical rotatory dispersion of proteins and polypeptides.

Conformation of Proteins and Polypeptides. Ii. Optical Rotatory Dispersion and Conformation of the Milk Proteins and Other Proteins in Organic Solvents.

The study of the optical rotatory properties of synthetic polypeptides in organic solvents has contributed considerably to our understanding of the structural organization of globular proteins. However, in contrast to the extensive literature which has accumulated in the past decade on the various polyamino acids (l-3), relatively little work has been done on actual proteins in organic solvents...

APPLICATION OF TWO-DIMENSIONAL ELECTROPHORESIS AND NIH 3T3 CELL TRANSFECTION ASSAY IN THE STUDY OF TUMOR-AS SOCIATED PROTEINS AND GENOMIC DNA TUMOROGENICITY IN MALIGNANT HUMAN ESOPHAGEAL SPECIMENS

Total protein and DNA extracted from histologically diagnosed normal nonmalignant and esophageal tumor tissues were used for analysis of polypeptides pattern by two-dimensional gel electrophoresis and DNA transforming activity in NIH 3T3 cell transfection assay, respectively. In comparison to normal tissues, eight polypeptides underwent down-regulation or disappeared, while seven polypeptid...

Membrane optical activity: some facts and fallacies.

The circular dichroism of hypothetical, water-filled, spherical shells, 75-3500 nm in radius, with walls 7.5 nm thick, composed of poly(L-lysine) in various conformational proportions, and suspended in water, were computed from the known optical properties of this polypeptide by classical general light-scattering theory (Mie theory). Comparison of the computed curves of circular dichroism spect...

Tandem Synthesis and Optical Rotatory Dispersion Studies of a Novel Spiro Lactone (methyl 3-(benzo[d]thiazol-2-ylamino)-7,9-dimethyl-2,6,8,10-tetraoxo-1-oxa-7,9-diazaspiro[4.5]dec-3-ene-4-carboxylate)

Spiro compounds are of interest due to their interesting conformational features and their structural implications on biological systems. The asymmetric characteristic of the molecule due to the chiral spiro carbon is one of the important criteria of the biological activities. These structures are a widespread structural motif found as key elements of numerous drugs and designed medicinal agent...